Path of Exile 2 continues the franchise's legacy of complex storytelling, intense combat, and intricate world-building. One of the many exciting quests in the game is Tribal Medicine, which introduces players to a fascinating storyline rooted in the indigenous tribes of Wraeclast. In this guide, we'll dive deep into the details of the Tribal Medicine quest, including its objectives, lore, rewards, and some tips to help you navigate this journey.

Whether you're a returning player or new to the Path of Exile series, this guide will give you the information you need to complete the Tribal Medicine quest efficiently and reap the rewards that come with it. This will help you more quickly earn rewards like POE 2 Currency in-game.

1. Quest Overview: The Tribal Medicine Quest

In Path of Exile 2, players will encounter the Tribal Medicine quest early in Act 3, a pivotal stage in the game's storyline. The quest is centered around the ancient, ritualistic practices of the native tribes in Wraeclast. The tribes have long had their own medicinal knowledge passed down through generations, and their spiritual connection to the land makes their practices unique and powerful.

As you progress through the game, you'll discover that these tribes are facing a crisis. A mystical illness has begun to spread among the elders, severely disrupting their ability to perform their sacred rites. The player is tasked with investigating this ailment and gathering the rare ingredients required to craft a potent tribal medicine that can heal the infected.

The quest also unravels important lore about the game's world, revealing how the tribes' medicine ties into the broader conflict with Wraeclast's corrupted forces, including some unsettling truths about the region's history.

2. Tribal Medicine Quest Objectives

The Tribal Medicine quest is divided into several parts, each of which introduces unique challenges and exploration elements. Below is a breakdown of the key objectives you'll need to complete during the quest:

a. Investigate the Ailment

Your first objective is to speak to Chieftain Koroa, the leader of one of the native tribes, who will explain the situation in detail. The tribe's elders have fallen ill after a series of disturbing visions and dreams. Koroa believes that the illness is connected to the corruption spreading across the land, and he implores you to investigate the source.

At this stage, you'll need to travel to a nearby sacred site where the disease first appeared. This site is heavily guarded by corrupted enemies who have been twisted by the same force affecting the tribe.

b. Gather Tribal Herbs

Upon learning more about the illness, you'll discover that the cure involves a rare mixture of tribal herbs, which grow in specific, difficult-to-reach areas. These herbs are vital for crafting the medicine needed to save the elders. The quest will send you to various locations to harvest these herbs, each surrounded by hostile wildlife, corrupted spirits, and dangerous mobs.

Key herbs you need to find include:

Koru Root: Known for its healing properties, this root is usually found near ancient ruins deep within the jungle.

Moonshard Fern: A rare fern that grows in the highest mountains of Wraeclast. The fern is extremely sensitive to environmental changes, and you'll need to complete a special puzzle to access it.

Ashleaf Sprigs: These sprigs grow in fire-scorched areas, often found near volcanoes or areas where intense magical energy is present.

These herbs will require you to traverse various challenging environments, each with its own set of combat and environmental puzzles. You'll have to use your wits and combat skills to collect the herbs while keeping an eye out for rare, hidden items that might help in crafting the medicine.

c. Craft the Tribal Medicine

Once you've gathered all the necessary ingredients, you'll return to Chieftain Koroa to begin the crafting process. The game introduces a tribal crafting station, a new mechanic where you'll combine the herbs using a specific ritual, guided by Koroa's knowledge of his tribe's ancient practices.

The process will be straightforward, but it will require you to complete ritual challenges by using your skills in crafting and magic. The items you create will not only be used to heal the elders but also have side benefits that can improve your defensive stats, such as resistance to poison, life regeneration, or mana recovery.

d. Administer the Medicine

Once the medicine is crafted, you'll need to administer it to the elders who are suffering from the ailment. This involves delivering the medicine to multiple locations across the map, where the tribal leaders are scattered. Along the way, you will encounter various mini-bosses and mini-quests that require tactical decisions to navigate safely.

When you administer the medicine, you'll trigger a series of cutscenes that delve deeper into the lore of the indigenous tribes and their role in the fight against corruption. The healing process is not instantaneous, and you'll have to fight off any last-minute interruptions from corrupted entities attempting to prevent the medicine's application.

Once all the elders are healed, you'll complete the quest, gaining their blessing and unlocking a new area for exploration-known as the Sacred Grove-which serves as a hub for future quests related to the tribes.

3. Rewards for Completing Tribal Medicine

Completing the Tribal Medicine quest not only progresses the storyline but also provides significant rewards, both in terms of lore and tangible in-game benefits. Here are the main rewards you'll receive:

a. Unique Tribe Relics

By successfully healing the tribe's elders, you'll gain access to unique relics. These relics, tied to the ancient knowledge of the tribes, provide powerful bonuses, such as:

Herbalist's Charm: A unique amulet that enhances health regeneration and resistance to poison.

Shamanic Cloak: A piece of armor that increases mana regeneration and elemental resistances, offering defense against elemental damage.

b. Crafting Materials

The quest also provides valuable crafting materials, some of which are exclusive to the Tribal Medicine questline. These can be used in your future crafting endeavors to create powerful gear, upgrade existing equipment, or even sell to vendors for a high price.

c. Access to the Sacred Grove

As mentioned, upon completion of the quest, you unlock access to the Sacred Grove, a mysterious area filled with ancient trees and mystical flora. Here, you can interact with the Elder Shamans to receive further quests and learn about the deeper lore of the tribes. This area will also provide opportunities to craft special healing potions, buffs, and utility items that can be invaluable in future battles.

d. Reputation with Tribal Factions

The quest helps build reputation with the various tribal factions scattered throughout Wraeclast. Increased reputation unlocks additional quests, poe2 trade opportunities, and rare crafting options. These factions also offer valuable insight into the game's broader conflicts, adding a layer of complexity to your decisions in the game.

4. Tips for Completing the Tribal Medicine Quest

Here are some important tips to make your experience with the Tribal Medicine quest smoother:

Preparation is Key: Make sure to stock up on healing items, particularly antidotes and elixirs, as the areas you'll be exploring are filled with venomous creatures and corrupt entities that deal elemental damage.

Check for Hidden Paths: The environments where you'll gather the herbs often contain hidden passages or secret areas that contain additional lore and rewards. Be sure to explore every nook and cranny to maximize your loot.

Use Mobility: Many of the environments in the quest require swift movement and avoidance of environmental hazards like fire, poison, and falling rocks. Keep your mobility skills ready for any situation.

Minion Support: If you're struggling with large groups of enemies, using minions can be very helpful. They can tank damage while you focus on dealing with ranged threats or healing.

Engage with Lore: The Tribal Medicine questline is rich in lore. Take the time to read the dialogues, look through the quest logs, and listen to the cutscenes. The deeper narrative not only enhances your understanding of the game but can also offer clues about upcoming content.

5. Conclusion

The Tribal Medicine quest in Path of Exile 2 is an engaging blend of lore, crafting, and combat, offering players a deep dive into the world of Wraeclast's indigenous tribes. The journey is not just about healing the elders-it's about uncovering a deeper mystery, gaining new powers, and understanding the cultural fabric of the game's world. By following this guide, you should be well-prepared to tackle the challenges and reap the rewards of this fascinating quest. Whether you're playing through the story for the first time or revisiting it, the Tribal Medicine quest promises to be a memorable chapter in your adventure.